NCT07320170

Comparative Effects of CGF and PRP in Impacted Third Molar Surgery

Evaluation of the Effects of Platelet-rich Plasma and Concentrated Growth Factor on Postoperative Pain, Swelling, and Alveolar Osteitis After Mandibular Third Molar Surgery: a Randomized Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Recep Tayyip Erdogan University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effects of two different blood products obtained from the patient's own blood (Concentrated Growth Factor \[CGF\] and Platelet-Rich Plasma \[PRP\]) on healing after wisdom tooth extraction. The aim is to determine whether applying these materials to the extraction area reduces postoperative pain, facial swelling, and the risk of dry socket compared to standard healing.

Detailed description

This prospective, randomized, controlled clinical trial compares the efficacy of autologous platelet concentrates in reducing postoperative sequelae following the surgical extraction of impacted mandibular third molars. A total of 42 patients were randomly assigned to one of three groups: Control Group: Standard surgical extraction without additional biomaterials. CGF Group: Standard extraction followed by the placement of a CGF clot into the extraction socket. PRP Group: Standard extraction followed by submucosal injection of PRP. The primary outcome measured is postoperative pain (Visual Analog Scale) on postoperative days 1, 3, and 7. The secondary outcomes include facial swelling (linear measurements) on postoperative days 1, 3, and 7, and the incidence of alveolar osteitis (dry socket).

Conditions

• Impacted Third Molar

Interventions

Type	Name	Description
BIOLOGICAL	Concentrated Growth Factor (CGF)	Standard surgical extraction followed by the placement of a Concentrated Growth Factor (CGF) clot into the extraction socket immediately after tooth removal.
BIOLOGICAL	Platelet-Rich Plasma (PRP)	Standard surgical extraction followed by submucosal injection of Platelet-Rich Plasma (PRP) around the extraction site.

Timeline

• Start date: 2024-05-02
• Primary completion: 2025-05-02
• Completion: 2025-05-02
• First posted: 2026-01-06
• Last updated: 2026-01-08

Locations

1 site across 1 country: Turkey (Türkiye)