NCT07319494

Advanced PRF vs PRF for Gap Filling in Immediate Implants

Comparison of Advanced Platelet Rich Fibrin Versus Platelet Rich Fibrin as a Gap Filling Material in Immediate Implant Placement

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

Study type: Clinical Trial Goal: The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement. Main questions it aims to answer: Does A-PRF provide greater buccal bone preservation compared to PRF after immediate implant placement? Does A-PRF improve soft tissue healing and reduce postoperative complications compared to PRF? Comparison group: Researchers will compare A-PRF to PRF as a gap-filling material in immediate implants to see if A-PRF results in better bone and soft tissue outcomes. Participants will: Undergo tooth extraction followed by immediate implant placement Receive either A-PRF or PRF as the gap-filling material in the implant site Have CBCT scans at baseline and 6 months to measure bone thickness Have clinical assessments of soft tissue healing and implant stability Attend follow-up visits at 1 week, 1 month, 3 months, and 6 months post-surgery

Conditions

• Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material

Interventions

Type	Name	Description
PROCEDURE	Immediate Dental Implant and A-PRF	Arm 1: Advanced Platelet-Rich Fibrin (A-PRF) Participants will have a tooth extracted, the socket cleaned, and A-PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.
PROCEDURE	Immediate dental implant and PRF	Arm 2: Platelet-Rich Fibrin (PRF) Participants will have a tooth extracted, the socket cleaned, and traditional PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.

Timeline

• Start date: 2025-06-25
• Primary completion: 2025-11-26
• Completion: 2026-02-15
• First posted: 2026-01-06
• Last updated: 2026-01-06

Locations

1 site across 1 country: Egypt