NCT07316582

Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis

Clinical and Biochemical Evaluation of Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management of Stage II Grade A Periodontitis: A Randomized Controlled Clinical Trial

• Status: Enrolling By Invitation
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

melatonin loaded in injectible platelet rich fibrin in treatment of periodontitis

Conditions

• Periodontitis Stage II

Interventions

Type	Name	Description
DRUG	Melatonin-Loaded Injectable Platelet-Rich Fibrin	patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection
BIOLOGICAL	injectible platelet rich fibrin (i-PRF )	patients will be included in this group receiving (SRP) with local application of i-PRF

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-06-01
• Completion: 2026-07-01
• First posted: 2026-01-05
• Last updated: 2026-01-05

Locations

1 site across 1 country: Egypt