NCT07315282

The Effect of Oral Iron Supplements on Insulin and Glucose Metabolism in Overweight and Obese Women

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Nicole Stoffel · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The study will be a randomized, double-blind, 17-day metabolic intervention trial including 14 days of high-dose or low-dose iron supplementation. A total of 70 overweight or obese (OW/OB) women will be enrolled. Participants will be individually randomized into either the high-iron or low-iron group. Women in the low-iron group will receive 15 mg of iron as ferrous fumarate daily for 14 days, while women in the high-iron group will receive 195 mg of iron as ferrous sulfate daily for 14 days. The study consists of three visits in total. On Day 0, a fasting blood sample will be collected and an OGTT will be performed, with additional blood samples collected at 1 hour and 2 hours post-OGTT. The OGTT will be repeated on Day 14, after 14 days of oral iron supplementation, and again on Day 17, four days after oral iron supplementation has been stopped

Conditions

• Overweight and Obese Women

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	195 mg iron daily	3 x 65 mg iron as ferrous sulfate
DIETARY_SUPPLEMENT	15 mg iron daily	3 x 5 mg iron as ferrous sulfate

Timeline

• Start date: 2025-12-23
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2026-01-02
• Last updated: 2026-01-02

Locations

1 site across 1 country: Lebanon