NCT07310238

Dual-Task Improvement in Parkinson's Via rTMS

The Effect of Repetitive Transcranial Magnetic Stimulation on Dual-task Performance in Patients With Parkinson's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: University of Gaziantep · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex on cognitive function and dual-task performance in individuals with Parkinson's disease. Participants completed ten rTMS sessions over two weeks or received sham stimulation. Cognitive status was assessed using the Montreal Cognitive Assessment, and mobility was evaluated through single-task and multiple dual-task Timed Up and Go tests. The study examined whether rTMS could enhance cognitive abilities and improve motor-cognitive performance, which are commonly impaired in Parkinson's disease and contribute to reduced functional independence. Findings indicated that rTMS led to improvements in cognition, single-task mobility, and complex dual-task performance. The intervention was well tolerated, and no adverse events related to the stimulation intensity were reported.

Detailed description

Parkinson's disease often leads to declines in cognition, gait performance, and the ability to manage simultaneous cognitive-motor demands. These difficulties contribute to mobility limitations, fall risk, and loss of independence in older adults. This randomized controlled study investigates whether repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex can enhance cognitive function and improve single- and dual-task mobility performance in individuals with Parkinson's disease. Participants complete a two-week intervention consisting of active or sham stimulation. Standardized cognitive and functional mobility assessments are administered before and after the intervention to determine the extent of change associated with rTMS. The study is designed to provide preliminary evidence on whether neuromodulation of an executive-control region can support functional motor-cognitive interactions in this population.

Conditions

• Parkinson Disease (PD)
• Cognition Disorders
• Gait Disorders, Neurologic
• Dual Task

Interventions

Type	Name	Description
DEVICE	Active Repetitive Transcranial Magnetic Stimulation (rTMS)	Repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex using a figure-8 coil. Stimulation delivered at 5 Hz, 120% of the resting motor threshold, 600 pulses per session, for 10 sessions over two weeks.
DEVICE	Sham Repetitive Transcranial Magnetic Stimulation	Sham stimulation performed using the same coil placement, session duration, and procedures as the active rTMS condition, but without magnetic output. Sessions matched in schedule and structure to the active intervention.

Timeline

• Start date: 2022-11-15
• Primary completion: 2025-11-15
• Completion: 2025-11-15
• First posted: 2025-12-30
• Last updated: 2025-12-30

Locations

1 site across 1 country: Turkey (Türkiye)