NCT07308249

Brain Network fMRI Analysis in Proprioceptive Training for Chronic Low Back Pain

Research on the Application of Brain Network Functional Connectivity Analysis Based on Functional Magnetic Resonance Imaging in Proprioceptive Training for Chronic Non-Specific Low Back Pain

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically reveals the central neural remodeling patterns in CNLBP and establishes an objective efficacy evaluation system based on multimodal imaging.

Detailed description

This phase of the research aims to elucidate the neuroplasticity mechanisms induced by CNLBP treatment, providing a theoretical basis for the future development of personalized rehabilitation protocols based on brain network subtypes, ultimately achieving the clinical goals of reducing pain recurrence rates and improving long-term prognosis in patients.

Conditions

• Brain Network Functional Connectivity

Interventions

Type	Name	Description
OTHER	Multimodal Imaging Evaluation	Functional connectivity analysis of brain networks based on functional magnetic resonance imaging (fMRI) technology

Timeline

• Start date: 2025-12-20
• Primary completion: 2028-12-30
• Completion: 2028-12-30
• First posted: 2025-12-29
• Last updated: 2025-12-29