NCT07305207

Establishing a Controlled Human Infection Model for Influenza H3N2 as a Foundation for Pandemic Preparedness

A Double-blinded, Phase 1 Clinical Trial to Establish an RG-A/Texas/71/2017 (H3N2) Influenza Controlled Human Infection Model (CHIM) That Safely and Reproducibly Induces Symptomatic Influenza Virus Infection in Healthy Adults 18-45 Years of Age After Intranasal Challenge

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: Dalhousie University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The overall objective is to establish an influenza Controlled Human Infection Model (CHIM) in Canada that can be used to assess the safety and efficacy of candidate vaccines, biologics, and therapeutics targeting influenza viruses.

Conditions

• Influenza (Healthy Volunteers)

Interventions

Type	Name	Description
BIOLOGICAL	Intranasal inoculation of RG-A/Texas/71/2017 (H3N2) influenza in each naris on Day 1 of the study.	Participants will be inoculated intranasally with a single dose of the A/H3N2 challenge virus or placebo

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-06-01
• Completion: 2028-01-31
• First posted: 2025-12-26
• Last updated: 2025-12-26