NCT07302659

Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG

Surgical Techniques to Prevent Perioperative Neurologic Complications in Patients Undergoing Coronary Artery Bypass Grafting

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 380 (estimated)
• Sponsor: China National Center for Cardiovascular Diseases · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically: This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.

Conditions

• Coronary Artery Bypass Graft (CABG)

Interventions

Type	Name	Description
PROCEDURE	Aortic no-touch coronary artery bypass grafting (RIMA-SVG)	Ascending aortic no-touch CABG with saphenous vein graft (SVG) anastomosed to the right internal mammary artery (RIMA)
PROCEDURE	Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)	Off-pump CABG with proximal saphenous vein graft (SVG) anastomoses constructed on the ascending aorta using a partial-occlusion (side-biting) clamp.

Timeline

• Start date: 2026-03-10
• Primary completion: 2027-12-31
• Completion: 2028-06-30
• First posted: 2025-12-24
• Last updated: 2026-04-14

Locations

4 sites across 1 country: China