NCT07302191

High-Intensity Interval or Concurrent Exercise on Oxidative Stress and Inflammation in Obese Women

Comparable Reductions in Health Biomarkers Following High-Intensity Interval or Concurrent Training in Obese Postmenopausal Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: University of Valladolid · Academic / Other
• Sex: Female
• Age: 50 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Introduction: Menopause is associated with body composition change, an increase in the cardio-metabolic risk factor for oxidative stress. Nevertheless, it has been suggested that regular physical training is an effective non-pharmacological intervention to reduce oxidative stress and cardio-metabolic disorders in menopausal individuals. Therefore, the present study was conducted to compare the effects of twelve weeks of high-intensity interval training (HIIT) and concurrent (Conc) and on body composition, cardio-metabolic indices and oxidative stress in sedentary obese postmenopausal women. Materials and methods: Forty-five menopausal obese women voluntarily participated and were randomly assigned into three groups: a) HIIT (6-12×60s of high intensity training (85-95% HRMax) and then running for 60 seconds with low intensity (55-60% HRMax)), b) concurrent endurance (performed on training with 55-75% HRMax) and strength training (including two sets in eight exercise stations with 55-75% 1RM)) and c) control group. Training programs were done for twelve weeks, 3 times per week. Body composition, cardio-metabolic indices and oxidative stress markers were measured before and after twelve weeks of exercise training program.

Conditions

• Women Veterans
• Obese Women
• Postmenopausal
• Sedentary Lifestlye

Interventions

Type	Name	Description
BEHAVIORAL	High-Intensity Interval	HIIT consisted of alternating high- (90-95 % HR\_max) and low-intensity (55-60 % HR\_max) aerobic bouts
BEHAVIORAL	concurrent training	combined aerobic and resistance exercises
BEHAVIORAL	Control Group	usual daily routines

Timeline

• Start date: 2025-09-02
• Primary completion: 2025-11-20
• Completion: 2025-12-08
• First posted: 2025-12-24
• Last updated: 2025-12-31

Locations

1 site across 1 country: Spain