NCT07300696

Functional MRI for Monitoring Progression and Assessing Trends in ILD

Functional Magnetic Resonance Imaging of the Lung to Detect Regional Reversibility and Progression in Interstitial Lung Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: University Hospital Heidelberg · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives: Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different. Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs. Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

Conditions

• Interstitial Lung Diseases (ILD)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Lung MRI Protocol with Functional and Contrast-Enhanced Sequences	Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.

Timeline

• Start date: 2025-11-20
• Primary completion: 2027-02-01
• Completion: 2027-07-01
• First posted: 2025-12-24
• Last updated: 2025-12-24

Locations

2 sites across 1 country: Germany