NCT07300007

PK and Relative Bioavailability of Liquid Metformin vs Tablets in Healthy Adults

An Open-Label, Randomized, Crossover Study to Characterize the Pharmacokinetics and Relative Bioavailability of Liquid Metformin at 100 mg/mL and 250 mg/mL Compared With Standard Metformin Tablets

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Aspargo Labs, Inc · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The study will evaluate the pharmacokinetics and relative bioavailability of two liquid metformin formulations (100 mg/mL and 250 mg/mL)

Detailed description

The study will compare the pharmacokinetic profiles of two liquid metformin formulations (100 mg/mL and 250 mg/mL) with a standard metformin immediate-release tablet.

Conditions

• Healthy Volunteer

Interventions

Type	Name	Description
DRUG	Liquid Metformin 100 mg/mL	A single oral dose of liquid metformin at a concentration of 100 mg/mL will be administered under fasting conditions in one treatment period of the crossover.
DRUG	Liquid Metformin 250 mg/mL	A single oral dose of liquid metformin at a concentration of 250 mg/mL will be administered under fasting conditions in one treatment period of the crossover.

Timeline

• Start date: 2026-03-15
• Primary completion: 2026-05-15
• Completion: 2026-05-28
• First posted: 2025-12-23
• Last updated: 2025-12-23

Regulatory

• FDA-regulated drug study