NCT07298967

ORCHARDS-AIR Study

ORegon CHild Absenteeism Due to Respiratory Disease Study - Air Surveillance

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 422 (estimated)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 4 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this observational study is to compare the effectiveness of air surveillance and to better understand the relationship between household transmission and viruses detected in the air. Participants will provide nasal swabs and have an air sample surveillance device installed in their home.

Detailed description

The purpose of ORCHARDS-AIR is to utilize air surveillance in participant homes in conjunction with individually collected nasal specimens to assess their concordance and evaluate the significance of airborne detection with household transmission of common respiratory pathogens such as influenza and SARS-CoV-2. The researchers postulate that households with documented and probable respiratory pathogen transmission will have higher rates of in-home air surveillance detection. Students with more severe illnesses will be absent more often and spend more time at home, potentially leading to absenteeism being associated with greater air surveillance detections and intrahousehold transmission.

Conditions

• Acute Respiratory Infection
• Influenza-like Illness

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Nasal swab	Participants will use a swab to collect nasal specimens
DEVICE	Indoor air quality monitor	InBio Apollo ambient air sampler to be run in the home for the duration of study participation. Material from the air, like aerosols, dust particles, and other environmental material, are collected on sampler filler material.

Timeline

• Start date: 2026-01-07
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2025-12-23
• Last updated: 2026-01-22

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study