Trials / Active Not Recruiting

Active Not RecruitingNCT07298759

The Effect of Hydroxytyrosol Administration on Superoxide Dismutase, Pulsatility Index and Resistance Index of Uterine Artery Doppler and Flow-Mediated Dilatation of Brachial Artery In Mothers With Hypertension In Pregnancy

Status: Active Not Recruiting
Phase: N/A
Study type: Interventional
Enrollment: 52 (actual)

Sponsor: Dr Cipto Mangunkusumo General Hospital · Academic / Other
Sex: Female
Age: —
Healthy volunteers: Not accepted

Summary

The purpose of this clinical trial is to evaluate the effect of hydroxytyrosol 10 mg/day administered for 4 weeks in pregnant individuals with hypertension. This study will assess whether hydroxytyrosol increases serum superoxide dismutase levels, reduces uterine artery Doppler pulsatility and resistance indices, and improves brachial artery flow-mediated dilation. Participants will be randomly assigned to receive either hydroxytyrosol or a matching placebo. Both products will be visually identical to ensure blinding. Participants will take two capsules daily for 4 weeks and attend two study visits for assessments and follow-up.

Conditions

Hypertension in Pregnancy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Placebo oral capsule identical in appearance to hydroxytyrosol supplement, administered twice daily for 4 weeks.
DIETARY_SUPPLEMENT	Hydroxytyrosol	Hydroxytyrosol is a natural polyphenol with antioxidant and anti-inflammatory properties, derived from olives. In this study, hydroxytyrosol 10 mg will be administered orally twice daily for 4 weeks to assess its effects on blood vessels and inflammatory biomarkers in hypertensive pregnant women.

Timeline

Start date: 2025-06-11
Primary completion: 2025-12-31
Completion: 2026-02-01
First posted: 2025-12-23
Last updated: 2026-01-07

Locations

1 site across 1 country: Indonesia

Source: ClinicalTrials.gov record NCT07298759. Inclusion in this directory is not an endorsement.