NCT07297225

Metabolic Dysfunction-Associated Fatty Liver Disease Impairs Intraoperative Indocyanine Green Fluorescence Cholangiography Quality: Development and Validation of a Predictive Model

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 150 (actual)
• Sponsor: Zhujiang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Near-infrared fluorescence cholangiography has been shown to improve the clinical outcomes of laparoscopic cholecystectomy (LC). However, it remains unclear whether hepatic steatosis in patients with metabolic dysfunction-associated fatty liver disease (MAFLD) influences the quality of indocyanine green fluorescence imaging (ICG-FI), and whether the quality can be predicted preoperatively. This study aimed to evaluate the impact of MAFLD on intraoperative fluorescence quality and to develop a multiple linear regression model for predicting intraoperative ICG-FI.

Conditions

• MAFLD
• Cholecystitis
• Gallbladder Polyps
• Cholelithiasis

Interventions

Type	Name	Description
OTHER	Retrospective observational study without intervention measures	Retrospective observational study without intervention measures

Timeline

• Start date: 2025-01-31
• Primary completion: 2025-05-30
• Completion: 2025-08-20
• First posted: 2025-12-22
• Last updated: 2025-12-22

Locations

1 site across 1 country: China