NCT07296146

Probiotics Against Erythropoietin Resistance in Chronic Kidney Disease Patients.

Effect of Probiotic Supplementation on Resistant Anaemia to Erythropoietin in Chronic Kidney Disease Patients.

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Badr University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to assess whether probiotic supplementation can improve the hematological response of CKD patients to erythropoietin therapy and prevent or reduce erythropoietin resistance. The main questions it aims to answer are: Can probiotic be used as an adjuvant strategy in anemia management and increasing ESA responsiveness in CKD? What medical problems do participants have when taking probiotic? Researchers will compare Erythropoietin only with Erythropoietin + Probiotic to see if Probiotic aids in treating anaemic chronic kidney disease patients. Participants will: Take Erythropoietin + Probiotic or Probiotic only every day for 3 months Visit the clinic once every 4 weeks for checkups and tests Keep a diary of their symptoms

Conditions

• Anaemia
• Chronic Kidney Disease
• Regular Hemodialysis

Interventions

Type	Name	Description
DRUG	Erythropoietin + Probiotic	Anaemic chronic kidney disease patients on regular hemodialysis treated with Erythropoietin + Probiotic
DRUG	EPO	Anaemic chronic kidney disease patients on regular hemodialysis treated with Erythropoietin

Timeline

• Start date: 2025-12-15
• Primary completion: 2026-03-15
• Completion: 2026-05-15
• First posted: 2025-12-22
• Last updated: 2025-12-22