NCT07292753

Vitamin D Versus Desmopressin Versus Combination Therapy in Children With Primary Monosymptomatic Nocturnal Enuresis and Vitamin D Deficiency

Role of Vitamin D Supplementation Versus Desmopressin Versus Their Combination in the Treatment of Primary Monosymptomatic Nocturnal Enuresis in Children With Vitamin D Deficiency: A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 6 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

This randomized clinical trial evaluated three treatment approaches for children aged 6 to 12 years who had primary monosymptomatic nocturnal enuresis (night-time bedwetting) and confirmed vitamin D deficiency. Bedwetting is common in school-aged children and can affect self-esteem, social interactions, and school performance. Although desmopressin is widely used, some children do not respond adequately. Previous studies suggested that low vitamin D levels might contribute to bedwetting, raising the possibility that vitamin D supplementation could help. In this study, eligible children were randomly assigned to one of three groups: 1. vitamin D supplementation alone, 2. desmopressin alone, or 3. a combination of vitamin D and desmopressin. All participants were followed for up to six months. The primary aim was to compare the improvement in the number of wet nights per week among the three groups. Secondary assessments included treatment tolerability, changes in vitamin D levels, changes in serum sodium, and any treatment-related side effects.

Conditions

• Nocturnal Enuresis
• Vitamin D Deficiency

Interventions

Type	Name	Description
DRUG	Vitamin D	Oral vitamin D supplementation used to correct vitamin D deficiency in children with primary monosymptomatic nocturnal enuresis.
DRUG	Desmopressin	Oral desmopressin used as antidiuretic therapy for primary monosymptomatic nocturnal enuresis in children.

Timeline

• Start date: 2024-12-15
• Primary completion: 2025-10-10
• Completion: 2025-10-10
• First posted: 2025-12-18
• Last updated: 2026-03-17

Locations

1 site across 1 country: Egypt