NCT07288905

Exploring the Effects of Exercise Combined With BFRT on Healthy and Patients With CKD

The Feasibility and Effects of Exercise Training Combined With Blood Flow Restriction Training on Exercise Capacity and Exercise Tolerance in Patients With Chronic Kidney Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: National Cheng Kung University · Academic / Other
• Sex: All
• Age: 20 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in healthy and CKD patients

Detailed description

Chronic kidney disease (CKD) is a condition characterized by impaired kidney function lasting for more than 3 months, as estimated by the glomerular filtration rate (eGFR), which is classified into stages 1 to 5. Common symptoms include swelling, fatigue, and high blood pressure. Previous studies have indicated that physical inactivity in patients with CKD, often due to fatigue, leads to decreased physical fitness. In addition, secondary complications such as muscle mass loss and weakness are frequently observed, especially in the advanced stages of CKD. To address this vicious cycle, aerobic and resistance training have been shown to mitigate these effects. Previous studies have reported that such exercise interventions can reduce fatigue and improve VO₂ peak in individuals with CKD. However, these exercise programs often involve high loads and frequencies, which may not be feasible for some CKD patients, particularly those with comorbidities such as diabetes or cardiovascular disease. The effectiveness of blood flow restriction (BFR) exercise compared with high-load training has been demonstrated in older adults, showing improvements in functional ability and muscular adaptation. Therefore, the purpose of this study is to investigate the effects of incorporating blood flow restriction during exercise on cardiopulmonary function and exercise capacity in patients with CKD.

Conditions

• Chronic Kidney Disease

Interventions

Type	Name	Description
BEHAVIORAL	Aerobic exercise	The aerobic exercise intervention will utilize stationary bike. The program will be conducted 2 times per week over a 12 weeks
BEHAVIORAL	Blood flow restriction	Blood flow restriction intervention will combined aerobic exercise and resistance exercise. The program will be conducted 2 times per week over a 12 weeks
BEHAVIORAL	Resistance exercise	The resistance exercise will bilateral leg extension. The program will be conducted 2 times per week over a 12 weeks
BEHAVIORAL	Disease and exercise suggestion	The participants will received self-care technique and home-based exercise approach

Timeline

• Start date: 2025-10-04
• Primary completion: 2027-12-31
• Completion: 2030-12-31
• First posted: 2025-12-17
• Last updated: 2025-12-17

Locations

1 site across 1 country: Taiwan