NCT07287306

Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals

Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 375 (estimated)
• Sponsor: Wecare Probiotics Co., Ltd. · Industry
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Gut microbiota play a key role in polyphenol metabolism, participating in the breakdown of dietary components and producing various small molecule metabolites that affect human health. However, little is currently known about how gut microbes metabolize dietary compounds and produce bioactive metabolites. This study aims to use metabolomics to precisely identify food-derived metabolites in the blood to investigate whether probiotics (BLa80, LRa05) can enhance the breakdown of dietary components and improve their absorption and utilization in the human body.

Conditions

• Healthy Individuals

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	The experimental phase of this study will last 8 weeks and each subject will receive 3 follow-up visits (week 0, week 4, week 8).
DIETARY_SUPPLEMENT	BLa80	The experimental phase of this study will last 8 weeks and each subject will receive 3 follow-up visits (week 0, week 4, week 8).
DIETARY_SUPPLEMENT	LRa05	The experimental phase of this study will last 8 weeks and each subject will receive 3 follow-up visits (week 0, week 4, week 8).

Timeline

• Start date: 2025-12-10
• Primary completion: 2026-06-20
• Completion: 2026-11-15
• First posted: 2025-12-17
• Last updated: 2025-12-17

Locations

1 site across 1 country: China