NCT07285096

P-CABs-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication

Efficacy and Safety of P-CABs-Based Bismuth Quadruple Therapy for First-line Helicobacter Pylori Eradication: A Multicenter Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,730 (estimated)
• Sponsor: Yueyue Li · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Bismuth-containing quadruple therapy was recommended as a first-line treatment for Helicobacter pylori infection. This study aimed to compare real-world outcomes of various potassium-competitive acid blockers (P-CABs) -based bismuth quadruple regimens and identify factors influencing treatment failure. A multicenter cohort study was conducted and study outcomes included eradication rates and incidence of adverse events.

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
OTHER	Doctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures	Doctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures.

Timeline

• Start date: 2025-12-16
• Primary completion: 2026-06-01
• Completion: 2026-08-01
• First posted: 2025-12-16
• Last updated: 2025-12-23

Locations

1 site across 1 country: China