NCT07280507

Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction

Comparative Evaluation of Microneedling With Injectable PRF and Hyaluronic Acid for Papilla Reconstruction: A Randomized Clinical Trial

• Status: Active Not Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 7 (estimated)
• Sponsor: King Abdulaziz University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.

Conditions

• Papilla Reconstruction

Interventions

Type	Name	Description
BIOLOGICAL	Injectable Platelet Rich Fibrin	Injectable Platelet Rich Fibrin
OTHER	Hyaluronic Acid (HA)	Filler

Timeline

• Start date: 2025-11-24
• Primary completion: 2026-03-01
• Completion: 2026-09-30
• First posted: 2025-12-12
• Last updated: 2025-12-12

Locations

1 site across 1 country: Saudi Arabia