NCT07280403

Effect of a Low-carbohydrate Diet on Weight Loss in People Using the Injectable GLP-1 Agonist Semaglutide for Weight Loss

Effect of a Low-carbohydrate Diet on Weight Loss in People Using the Injectable GLP-1 Agonist Semaglutide for Weight Loss: a Pilot Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: INQUIS Clinical Research · Industry
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to determine the effect of a low carbohydrate higher protein diet, modelled after the Atkins program on weight loss, glycemic control, risk markers of cardiovascular disease and body composition in patients taking semaglutide. Participants will: * Be randomized to follow either a low carb, higher protein diet or a low fat diet for 3 months. * Visit the clinic at week 2, 4, 8 and 12 to meet with a dietician, fill out a symptoms questionnaire and for bloodwork * Complete 3-day food records 4 times over the 12 weeks.

Conditions

• Weight Loss

Interventions

Type	Name	Description
BEHAVIORAL	Low Carbohydrate	Low carbohydrate diet
BEHAVIORAL	Low Fat	Low fat diet

Timeline

• Start date: 2024-09-12
• Primary completion: 2025-10-14
• Completion: 2025-11-30
• First posted: 2025-12-12
• Last updated: 2026-02-18

Locations

1 site across 1 country: Canada