NCT07280195

ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty

• Status: Enrolling By Invitation
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 86 (estimated)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if local intra-operative application of ZYNRELEF (topical medication) during shoulder replacement surgery improves pain control (as defined by opioid consumption after surgery) compared to the use of an interscalene block with catheter. This is a randomized clinical trial without blinding. Subjects will complete patient reported outcomes before and after surgery. Subjects will track their narcotic use, pain scores and pain satisfaction after surgery.

Conditions

• Total Shoulder Arthroplasty
• Pain Management

Interventions

Type	Name	Description
DRUG	Zynrelef	ZYNRELEF
DRUG	Bupivacaine	Interscalene block with continuous catheter pump

Timeline

• Start date: 2026-02-14
• Primary completion: 2026-12-01
• Completion: 2027-12-01
• First posted: 2025-12-12
• Last updated: 2026-02-19

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study