NCT07280039

Mortality and Muscle Mass Loss in Critically Ill Patients.

Mortality and Muscle Mass Loss in Critically Ill Patients: A Prospective, Observational, Multicenter Study.

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 386 (estimated)
• Sponsor: Brno University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasoud for measurement the rectus femoris cross sectional area.

Detailed description

All patients will be admitted to participating ICU centers from December 2025 to December 2026 will be screened and enrolled based on the inclusion and exclusion criteria. Informed consent will be requested. Ultrasound measurements will be performed by the same investigator within the first 24h after ICU admssion and again on day 7 of the patient´s ICU stay. All patient data will be entered into case report form by a study physician. In the follow-up will be determined 28 mortality.

Conditions

• Mortality
• Muscle Loss

Timeline

• Start date: 2025-12-15
• Primary completion: 2025-12-15
• Completion: 2026-12-15
• First posted: 2025-12-12
• Last updated: 2025-12-12

Locations

1 site across 1 country: Czechia