NCT07279792

Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This randomized controlled trial will evaluate the efficacy of three bladder irrigation solutions - distilled water (DW), normal saline (NS), and hypertonic saline (HS) - as continuous bladder irrigation (CBI) following transurethral resection of non-muscle invasive bladder cancer (NMIBC). Short term (6 months) recurrence and progression free survival are mainly evaluated.

Conditions

• Bladder (Urothelial, Transitional Cell) Cancer
• Nonmuscle Invasive Bladder Cancer
• Irrigation
• Hypertonic Saline
• Normal Saline
• Distilled Water

Interventions

Type	Name	Description
DRUG	Continuous Bladder Irrigation with distilled water	Continuous Bladder Irrigation with distilled water post non muscle invasive bladder cancer urethral resection by endoscopy
DRUG	Continuous Bladder Irrigation with normal saline	Continuous Bladder Irrigation with normal saline post non muscle invasive bladder cancer urethral resection by endoscopy
DRUG	Continuous Bladder Irrigation with hypertonic saline	Continuous Bladder Irrigation with hypertonic saline post non muscle invasive bladder cancer urethral resection by endoscopy

Timeline

• Start date: 2024-10-01
• Primary completion: 2025-08-01
• Completion: 2025-09-01
• First posted: 2025-12-12
• Last updated: 2025-12-29

Locations

1 site across 1 country: Egypt