NCT07278388

Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2

Motivated Decision-Making and Performance

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.

Conditions

• PASC Post Acute Sequelae of COVID 19
• Fatigue

Interventions

Type	Name	Description
BEHAVIORAL	Physical Fatigue	Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.

Timeline

• Start date: 2025-07-16
• Primary completion: 2029-12-31
• Completion: 2029-12-31
• First posted: 2025-12-12
• Last updated: 2025-12-12

Locations

1 site across 1 country: United States