NCT07276633

Use of Subanesthetic Dose Propofol Before Extubation

Effect of Subanesthetic Dose Propofol Use Before Extubation on Recovery From Anesthesia, Agitation on Recovery, and Patient Satisfaction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Yuzuncu Yil University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty. Emergence agitation refers to restlessness and confusion during early recovery from anesthesia, which may affect patient safety and surgical conditions. The study evaluates agitation levels, recovery characteristics, and patient-reported comfort following propofol administration compared with standard care.

Detailed description

This study aims to evaluate whether administering a sub-anesthetic dose of propofol before extubation can reduce emergence agitation, enhance recovery characteristics, and improve patient comfort in adults undergoing rhinoplasty surgery. Emergence agitation is a common phenomenon during early recovery from general anesthesia and can involve restlessness, disorientation, and involuntary movements, potentially affecting patient safety and surgical outcomes. The study uses a randomized controlled design to compare peri-extubation responses between patients receiving low-dose propofol and those receiving standard care.

Conditions

• Emergence Agitation
• Rhinoplasty
• Patient Satisfaction

Interventions

Type	Name	Description
DRUG	Propofol (Sub-Anesthetic Dose)	Participants receive 0.5 mg/kg intravenous propofol as a single bolus 10 minutes before extubation.
OTHER	Normal Saline (Placebo)	Participants receive an equivalent volume of normal saline 10 minutes before extubation.

Timeline

• Start date: 2024-06-01
• Primary completion: 2024-09-01
• Completion: 2024-10-01
• First posted: 2025-12-11
• Last updated: 2025-12-11

Locations

1 site across 1 country: Turkey (Türkiye)