Trials / Recruiting
RecruitingNCT07276490
Central Haemodynamics and Pacing for AV Block
The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 124 (estimated)
- Sponsor
- University of Tartu · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Right ventricular pacing | Pacemaker implantation with RV lead placement |
| DEVICE | Conduction system pacing | Pacemaker implantation with conduction system (LBBAP) lead placement |
Timeline
- Start date
- 2025-11-28
- Primary completion
- 2027-06-01
- Completion
- 2027-12-31
- First posted
- 2025-12-11
- Last updated
- 2026-03-09
Locations
2 sites across 1 country: Estonia
Source: ClinicalTrials.gov record NCT07276490. Inclusion in this directory is not an endorsement.