NCT07275554

Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Qilu Hospital of Shandong University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the methylomic features of patients with hepatitis B-related acute-on-chronic liver failure and establish and validate a prognostic risk prediction classification model. The findings are of significant importance for guiding clinical practice and improving patient prognosis. Additionally, a methylomics-based classifier model for liver failure will be developed for disease prognosis analysis and clinical assessment, with the potential to enhance the diagnostic efficiency of liver failure.

Conditions

• HBV Related Acute-on-chronic Liver Failure
• HBV-related Liver Cirrhosis
• HBV (Hepatitis B Virus)

Timeline

• Start date: 2024-12-31
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-12-10
• Last updated: 2025-12-10

Locations

1 site across 1 country: China