NCT07271420

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis

Detailed description

This prospective, single-center treatment-withdrawal crossover study enrolled 10 patients on chronic peritoneal dialysis (PD) and uncontrolled hypertension (SBP \>140 mmHg and/or DBP \>90 mmHg). Following written informed consent, participants entered the treatment arm, receiving oral hydrochlorothiazide once daily on top of their standard of treatment for 90 days. This was followed by a 14-day washout period, after which participants entered a 90-day control period.

Conditions

• Hypertension
• Peritoneal Dialysis
• End Stage Kidney Disease (ESRD)

Interventions

Type	Name	Description
DRUG	Hydrochlorothiazide 25mg once per day	Thiazides diuretics

Timeline

• Start date: 2020-01-01
• Primary completion: 2026-12-31
• Completion: 2027-06-30
• First posted: 2025-12-09
• Last updated: 2025-12-09

Locations

1 site across 1 country: Hong Kong