NCT07267624

EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)

EARLY Antibiotics aDaptation in Ventilator-Acquired-Pneumonia Treatment After Implementation of a Broad-Panel Respiratory Multiplex PCR Test: A Multicenter Randomized Control Trial Conducted In Swiss Intensive Care Units. The EARLY ADAPT Study.

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 170 (estimated)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed ventilator-associated pneumonia, compared to standard diagnostic methods. As secondary objectives, the investigators will study antibiotic management and overall antibiotic consumption, as well as escalation or de-escalation events. The investigators will study the potential clinical impact of using multiplex PCR to see if the length of stay in the intensive care unit is reduced, as well as the duration of mechanical ventilation.

Conditions

• VAP - Ventilator Associated Pneumonia
• Antibiotic
• Antibiotic Stewardship
• Antibiotic Prescribing for Acute Respiratory-tract Infections
• Intensive Care (ICU)

Interventions

Type	Name	Description
DEVICE	PCR multiplex BioFire Pneumonia plus	In the intervention arm, in addition to traditional cultures for identifying pathogens and their resistance, multiplex PCR will be performed on the patient's respiratory samples. Empirical antibiotic therapy will be directly adapted to the results of multiplex PCR according to the guidelines provided.

Timeline

• Start date: 2026-01-05
• Primary completion: 2027-05-31
• Completion: 2027-11-30
• First posted: 2025-12-05
• Last updated: 2025-12-05

Locations

5 sites across 1 country: Switzerland

Regulatory

• FDA-regulated device study