NCT07267312

Premature Coronary Artery Disease and Familial Dyslipidemia in Patients Presenting With Acute Coronary Syndrome

Premature Coronary Artery Disease and Familial Dyslipidemia in Patients Presenting With Acute Coronary Syndrome: A Tertiary Cardiac Center Registry

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to explore the relationship between familial hypercholesterolemia and premature coronary artery disease, particularly in the context of acute coronary syndrome, by reviewing current evidence and highlighting the need for improved screening and aggressive lipid-lowering strategies in high-risk populations.

Detailed description

Dyslipidaemia and familial hypercholesterolemia (FH) are a common disorder that causes premature coronary artery disease. The lifelong burden of elevated low-density lipoprotein cholesterol (LDL-C) in FH accelerates endothelial dysfunction and plaque formation, often culminating in acute coronary syndrome (ACS) at a young age. ACS in patients with undiagnosed FH may be their first clinical manifestation, underscoring the importance of early identification and intervention.

Conditions

• Premature
• Coronary Artery Disease
• Familial Dyslipidemia
• Acute Coronary Syndrome

Interventions

Type	Name	Description
OTHER	Cardiovascular risk assessment	Participants underwent a standardized cardiovascular risk assessment that included detailed clinical evaluation, lipid profiling (Total Cholesterol, Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, and Triglycerides).

Timeline

• Start date: 2021-12-01
• Primary completion: 2025-03-27
• Completion: 2025-03-27
• First posted: 2025-12-05
• Last updated: 2025-12-05

Locations

1 site across 1 country: Egypt