NCT07265635

Functional Proteomics of Uremic Retention Solutes Associated With Immunosenescence, Inflammation and Impaired Adaptive Stress Response

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This is a randomized controlled crossover trial (58) in order to characterize PBL damage and death rate in hemodialysis patients treated with membranes with different permeability, including protein-leaking dialysers. The study will enroll fourty patients on regular 4-h three times per week hemodialysis (HD) of the dialysis unit of the "Fondazione IRCCS Policlinico San Matteo" (Pavia, Italy). Thirteen age and sex matched healthy individuals (Ctr) and ten CKD patients on peritoneal dialysis treatment (PD\*) will be included as healthy and CKD-matched controls, respectively. Comparison between HD and PD patients is aimed to assess the effect of biocompatibility and protein leakage during the treatments

Conditions

• Hemodialysis

Interventions

Type	Name	Description
DEVICE	HDF with PMMA	Hemodiafiltration with polymethyl methacrylate (PMMA)-based membrane
DEVICE	HDF	Hemodiafiltration without polymethyl methacrylate (PMMA)-based membrane

Timeline

• Start date: 2025-02-17
• Primary completion: 2027-02-17
• Completion: 2027-02-17
• First posted: 2025-12-05
• Last updated: 2025-12-05

Locations

1 site across 1 country: Italy