NCT07265102

Effect of a Mouthwash Containing Chlorhexidine and Chlorine Dioxide on Halitosis

A Randomized Double-Blind Crossover Clinical Trial Evaluating the Efficacy of a Mouthwash Containing Chlorhexidine and Chlorine Dioxide in Patients With Oral Malodor

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Can Tho University of Medicine and Pharmacy · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Halitosis significantly impacts the quality of a patient's life. This randomized, double-blind crossover trial evaluates a mouthwash containing chlorhexidine (0.01%) and chlorine dioxide (0.05%) compared with placebo. Forty participants rinsed twice daily for 2 weeks, followed by a 2-week washout and crossover. The primary outcomes were volatile sulfur compounds (H₂S, CH₃SH), measured by OralChroma. Secondary outcomes included plaque index, gingival index, bleeding on probing, tongue coating, and salivary bacterial counts (Aa, Pg, Fn, Pi, and Ec).

Conditions

• Halitosis

Interventions

Type	Name	Description
OTHER	CHX 0.01% + CDO 0.05% mouthwash	Mouthwash formulation containing chlorhexidine 0.01% and chlorine dioxide 0.05%, prepared by the Department of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City.
OTHER	Placebo mouthwash	Identical placebo formulation matched in flavor, color, and excipients but without active ingredients (CHX or CDO).

Timeline

• Start date: 2023-09-05
• Primary completion: 2023-12-05
• Completion: 2024-03-05
• First posted: 2025-12-04
• Last updated: 2025-12-22

Locations

1 site across 1 country: Vietnam