NCT07264946

Talocrural Manipulation and Ankle Muscle Architecture

The Effect of Talocrural Joint Manipulation on Ankle Muscle Architecture: A Randomized Crossover Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Bitlis Eren University · Academic / Other
• Sex: All
• Age: 45 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the effect of talocrural joint manipulation on the ankle muscle architecture in patients with stroke. This study was registered retrospectively due to the U.S. government shutdown (October 1 to November 12, 2025), which prevented timely registration despite prior intent to register prospectively.

Detailed description

The study, utilizing a randomized crossover design, is planned to be conducted on a minimum of 26 patients with stroke who meet the inclusion and exclusion criteria. Patients included in the study will be randomly assigned to receive both placebo talocrural joint manipulation and talocrural joint manipulation interventions. The study was originally intended to be registered prospectively. However, it was conducted during a period of administrative disruption related to the U.S. government shutdown (October 1 to November 12, 2025), which affected access to federal systems and delayed trial registration processes. As a result, registration could not be completed as planned, and the study was registered retrospectively (first submitted on November 22, 2025; first posted on December 4, 2025). The investigators confirm that the study protocol, including primary and secondary outcome measures, was finalized prior to the initiation of participant enrollment and remained unchanged throughout the study. This statement is provided to ensure transparency and to clarify that the delay in registration was due to circumstances beyond the investigators' control.

Conditions

• Stroke

Interventions

Type	Name	Description
OTHER	Placebo Talocrural Joint Manipulation	This intervention is a classic method used to evaluate the effect of talocrural joint manipulation.
OTHER	Talocrural Joint Manipulation	This technique, aiming to increase ankle dorsiflexion and mechanoreceptor activation, is based on the application of high velocity low amplitude traction to the joint.

Timeline

• Start date: 2025-10-10
• Primary completion: 2025-11-15
• Completion: 2025-11-15
• First posted: 2025-12-04
• Last updated: 2026-04-03

Locations

1 site across 1 country: Turkey (Türkiye)