NCT07263217

Mechanistic Study on the Protective and Regenerative Effects of Spirulina in Hepatectomy-Related Liver Injury

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if spirulina can help protect the liver and promote recovery after partial hepatectomy (surgery to remove part of the liver). It will also learn about the safety of spirulina in patients undergoing liver surgery. The main questions it aims to answer are: Does spirulina help improve liver function after surgery? Does spirulina promote liver regeneration and reduce inflammation? What side effects, if any, occur when participants take spirulina? Researchers will compare spirulina tablets to a placebo (a look-alike tablet that contains no spirulina) to see if spirulina helps protect the liver and support recovery after surgery. Participants will: Take spirulina or placebo tablets daily for 3 weeks before and 3 weeks after surgery. Provide blood and stool samples before and after treatment. Allow the collection of a small piece of liver tissue (from surgical waste) for analysis. Have regular clinic visits for checkups, blood tests, and safety monitoring.

Conditions

• Cholangiocarcinoma

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Spirulina	participants take spirulina tablets (2 g/day) for 3 weeks before and 3 weeks after surgery
DIETARY_SUPPLEMENT	Maltodextrin	Participants take placebo tablets (maltodextrin, same dosage and schedule).

Timeline

• Start date: 2025-10-01
• Primary completion: 2028-09-30
• Completion: 2028-09-30
• First posted: 2025-12-04
• Last updated: 2025-12-04

Locations

1 site across 1 country: China