NCT07261579

Composite Ratios Boost CRP's Power in Monitoring Ulcerative Colitis.

Composite Inflammatory Parameters Ratios Enforce the Role of CRP for Monitoring Ulcerative Colitis Disease Activity

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Inflammatory Bowel Disease (IBD) is a chronic, recurrent condition marked by disturbed levels of various hematological inflammatory cells and a deregulated immune environment. While C-reactive protein (CRP) is a key acute-phase reactant, its high levels can persist even after inflammation subsides. Other simple, cost-effective ratios, such as the Neutrophil-to-Lymphocyte Ratio (NLR), the Platelet-to-Lymphocyte Ratio (PLR), and Albumin-related ratios, also serve as promising, reproducible markers of systemic inflammation reflecting both immune status and nutrition. This study's objective is to evaluate the diagnostic performance of these various hematological inflammatory cellular components and CRP-related ratios (like the CAR) as predictors for Ulcerative Colitis (UC) disease severity, using colonoscopic and microscopic findings as the gold standard for comparison.

Conditions

• Ulcerative Colitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	C-Reactive Protein measuring CRP	5-ml peripheral blood samples were aseptically obtained for a complete blood count, and ELISA estimation of serum CRP
DIAGNOSTIC_TEST	CRP to Albumin Ratio	Serum CRP to albumin ratio (CAR) is a combination of markers for systemic inflammation and nutritional status

Timeline

• Start date: 2025-09-15
• Primary completion: 2025-11-25
• Completion: 2025-12-01
• First posted: 2025-12-03
• Last updated: 2026-01-21

Locations

1 site across 1 country: Egypt