NCT07256470

Salivary Replication of BK Virus in Post-kidney Transplant

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in the recipient. However, no study has investigated the possibility of respiratory transmission. This study would provide a better understanding of the pathophysiology of BK virus infection in kidney transplant recipients. The investigators would study viral replication of BK virus in saliva, urine and blood of patients who received a kidney transplant at the Amiens University Hospital. For this, the investigators will collect salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months as well as a urine and blood sample. The investigators will measure BK viral load in these three samples at different times.

Conditions

• BK Virus
• Salivary Replication
• Kidney Transplantation
• Nephropathy
• DNAemia

Interventions

Type	Name	Description
BIOLOGICAL	Salivary self-collection	Salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months

Timeline

• Start date: 2025-12-01
• Primary completion: 2027-04-01
• Completion: 2028-06-01
• First posted: 2025-12-01
• Last updated: 2025-12-08

Locations

1 site across 1 country: France