NCT07256431

Environmental Risk Factors in Multiple Sclerosis Development: Epidemiological Study of EBV Infection and Vitamin D Deficiency in RIS Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 110 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This is an ancillary study using samples collected in the ProBioRIS cohort (NCT06395662). The aim of the project is to highlight new biomarker candidates to assess the risk of conversion to clinically definite multiple sclerosis (CDMS) and disease activity (Evidence of Disease Activity) by taking into account demographic, clinical and MRI parameters. A cohort of healthy subjects will be integrated into the study to serve as a control population. We will study a panel of serum immunoglobulins targeting different Epstein Barr virus antigens to identify latency or reactivation phases. Identifying and prioritizing risk factors for clinical conversion to MS in radiologically isolated syndrome patients is of major importance for the implementation of personalized monitoring and treatment strategies, especially following the recent highlighting of the benefit of background treatments in patients at high risk of CDMS.

Conditions

• Radiologically Isolated Syndrome
• Epstein-Barr Virus Infections

Interventions

Type	Name	Description
OTHER	Antibiody titration	Search for EBV seropositivity using SIMAO assay

Timeline

• Start date: 2023-08-01
• Primary completion: 2024-07-30
• Completion: 2024-07-30
• First posted: 2025-12-01
• Last updated: 2025-12-01

Locations

1 site across 1 country: France