Trials / Recruiting
RecruitingNCT07256418
Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (estimated)
- Sponsor
- Centre Hospitalier Universitaire Dijon · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Skin samples | * Scleroderma group: skin biopsy for scleroderma patients * Control group: recovery of resected tissue from patients undergoing plastic, reconstructive and aesthetic surgery. |
| OTHER | Analysis of fibroblasts | Analysis of samples by RNA sequencing |
Timeline
- Start date
- 2026-01-26
- Primary completion
- 2027-01-01
- Completion
- 2027-01-01
- First posted
- 2025-12-01
- Last updated
- 2026-01-29
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT07256418. Inclusion in this directory is not an endorsement.