NCT07255742

Role of Lactoferrin in Prevention of Ventilator Associated Pneumonia in Neonates.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Dalia Mohamed Salah · Academic / Other
• Sex: All
• Age: 0 Days – 90 Days
• Healthy volunteers: Not accepted

Summary

The aim of the study is to 1. Evaluate the preventive value of Lactoferrin on VAP among ventilated neonates. 2. Evaluate the Primary outcome of Lactoferrin on: Sepsis, Feeding intolerance, Vomiting, Constipation or diarrhea 3. Evaluate the effect of Lactoferrin in critically ventilated neonates on: Incidence of VAP Duration of mechanical ventilation Duration of hospital stay

Detailed description

Randomised controlled trial

Conditions

• Ventilator Associated Pneumonia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lactoferrin in prevention of VAP	oral dose separate from feeds \[at a daily dose of 100mg/day\] via orogastric tube from first day of enrollment till time of successful extubation plus standard preventive measures of VAP; these include semi recumbent position, hand washing, suctioning when needed, endotracheal tube with subglottic secretion drainage, using heat and moisture exchanger filter, oral hygiene, changing of tubes only when needed and changing of ventilator circuit every 5 days.
OTHER	Control	They will receive standard preventive VAP strategies only.

Timeline

• Start date: 2025-08-01
• Primary completion: 2025-12-01
• Completion: 2025-12-04
• First posted: 2025-12-01
• Last updated: 2026-02-02

Locations

1 site across 1 country: Egypt