NCT07252596

Pain Neuroscience Education and Memory

Pain Neuroscience Education's Effect on Memory and Pain Drawings: An Exploratory Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Evidence In Motion · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Brief Summary: The goal of this observational study (case series) is to determine whether Pain Neuroscience Education (PNE) can influence memory function and sensory awareness in adults (18 years and older) experiencing chronic pain lasting more than one year. The main questions it aims to answer are: Does a single PNE session improve memory performance, as measured by the Montreal Cognitive Assessment (MoCA)? Does PNE change sensory awareness, as represented by alterations in body pain drawings using a grid overlay method? Participants will: Complete pre-intervention assessments, including: Numeric Pain Rating Scale (NPRS) Body chart drawing to map pain area Montreal Cognitive Assessment (MoCA) Pain Catastrophization Scale (PCS) Receive a 10-15 minute standardized PNE session delivered by a licensed clinician trained in pain science Complete the same assessments immediately after the intervention to identify any changes in memory, sensory awareness, and pain perception This study aims to explore whether PNE can positively impact cognitive and sensory functions affected by chronic pain, beyond its already-established effects on movement and pain intensity.

Detailed description

Detailed Description: Chronic pain is a complex, multidimensional condition affecting approximately 25% of the global population. It is increasingly understood through the lens of brain-based changes, particularly the dynamic pain connectome, a network of brain regions involved in sensory, cognitive, and emotional processing. Functional reorganization in chronic pain patients may contribute to clinical symptoms beyond pain, such as memory loss, decreased sensory awareness, and altered motor control. Pain Neuroscience Education (PNE) is an educational intervention that aims to reconceptualize a patient's understanding of pain to reduce fear-avoidance, pain catastrophization, and disability. Systematic reviews have demonstrated its effectiveness in reducing pain and improving movement. Early fMRI studies suggest that PNE may also deactivate pain-related brain areas and normalize brain function. This case series seeks to explore the impact of a single PNE session on cognitive (memory) and sensory (body perception) outcomes in individuals with chronic pain. Participants (aged 18 and older) who meet inclusion criteria and consent to the study will undergo pre- and post-intervention assessments. These include: Numeric Pain Rating Scale (NPRS) Pain body chart (grid overlay method) Montreal Cognitive Assessment (MoCA) Pain Catastrophization Scale (PCS) Following baseline assessments, participants will receive a 10-15 minute individualized PNE session delivered by licensed clinicians trained in advanced pain science. Immediately post-intervention, assessments will be repeated to evaluate changes. The study aims to contribute to the understanding of how PNE may influence brain-related symptoms associated with chronic pain, specifically memory function and sensory mapping. Findings could provide early evidence to support broader applications of PNE beyond movement-related outcomes.

Conditions

• Chronic Pain

Interventions

Type	Name	Description
BEHAVIORAL	Pain Neuroscience Education (PNE)	A 10-15 minute individualized educational session focusing on the neuroscience of pain. The session aims to reconceptualize the patient's understanding of their chronic pain by explaining the underlying biological, cognitive, and emotional mechanisms involved. Clinicians use a standardized checklist of metaphors and teaching tools tailored to the patient's clinical presentation.

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-02-01
• Completion: 2026-05-01
• First posted: 2025-11-26
• Last updated: 2025-11-26