NCT07252037

Dietary Guidelines for Americans-Ultra Processed Study

Impact of Dietary Guidelines Diets Containing Mostly Ultra-Processed Foods Compared to Less-Processed Foods on Biomarkers of Cardiometabolic Disease

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 79 (estimated)
• Sponsor: USDA Grand Forks Human Nutrition Research Center · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to test how processing food can affect how one's body responds to it.

Detailed description

The purpose of this project is to address the current gap in research on ultra-processed foods (UPFs) and cardiometabolic health with a feeding study that addresses the limitations of previously conducted intervention studies in matching UPF- and unprocessed- foods intervention diets for diet quality, nutrient content, and food type. Therefore, the primary objective is to evaluate diets composed primarily of ultra-processed or less processed foods that meet dietary guidelines recommendations on chronic disease risk factors. More specifically, when Dietary Guidelines for Americans (DGA)-compliant diets comprised of mostly ultra-processed and unprocessed foods (per Nova) are fed to generally healthy participants, determine whether there is an impact on: * blood pressure * fasting glucose and insulin concentrations, or * lipid panel (total cholesterol, HDL-C, LDL-C, triglycerides).

Conditions

• Overweight , Obesity
• Class I Obesity

Interventions

Type	Name	Description
OTHER	Low-processed DGA Diet	Participants will consume a DGA menu made up of low-processed foods over a 4-week period
OTHER	Ultra-processed DGA Diet	Participants will consume a DGA menu primarily made up of ultra-processed foods over a 4-week period

Timeline

• Start date: 2026-01-01
• Primary completion: 2029-12-01
• Completion: 2029-12-01
• First posted: 2025-11-26
• Last updated: 2025-11-26

Locations

1 site across 1 country: United States