NCT07249801

Closed-loop rTMS-EEG During Visuomotor Integration.

State-dependent Entrainment of Intrinsic Brain Rhythms to Improve Interregional Functional Coupling.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot study aims at establishing personalized state-based rTMS for precision neurorehabilitation, we designed a within-subject cross-over study to test closed-loop repetitive transcranial magnetic stimulation and electroencephalography (rTMS-EEG) comparing the targeting of two key nodes in the frontoparietal network during bimanual visuomotor force tracking in persons with upper extremity sensorimotor impairment affecting eye-hand control.

Detailed description

There is a need for oscillatory or repetitive neuromodulatory tools and methods that are effective in entraining intrinsic neural rhythms to improve inefficient functional coupling within neural circuits. The goal of the proposed study is to develop a closed-loop application of repetitive transcranial magnetic stimulation (rTMS) and electroencephalography (EEG) suitable for use in multidomain precision neural-circuit based rehabilitation studies that permits the time-locked application of rTMS pulses to the phase of the intrinsic neural oscillation (personalized state-based application) in a defined behavioral context (e.g., goal-directed eye-hand control).

Conditions

• Visuomotor Skills
• Brain Lesion (General)

Interventions

Type	Name	Description
DEVICE	repetitive transcranial magnetic stimulation (rTMS)	rTMS will be applied time-locked to the intrinsic brain rhythms to individually-defined brain regions

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-08-31
• Completion: 2027-08-31
• First posted: 2025-11-25
• Last updated: 2025-11-25

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study