NCT07247799

Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region

Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region: Retrospective Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 38 (actual)
• Sponsor: Andrea Scribante · Academic / Other
• Sex: All
• Age: 40 Years – 85 Years
• Healthy volunteers: —

Summary

The present study aims to evaluate the effectiveness of a combined protocol of professional and at-home ozone therapy in the treatment of oral mucositis in patients undergoing radio- and/or chemotherapy. In-office treatment was performed using a medical ozone generator, while at-home therapy involved the daily application of high-concentration ozonated oil products. The study assessed the reduction in mucositis severity (WHO scale), decrease in pain (VAS scale), and improvement in patient-reported quality of life, with specific attention to nutrition, oral hygiene, and treatment adherence.

Conditions

• Oral Mucositis
• Head and Neck Neoplasms

Interventions

Type	Name	Description
DEVICE	Ozone treatment	Ozone DTA (Sweden \& Martina SpA, 35020 Due Carrare, PD, Italy) for clinical application; home oral care with DentO3® toothpaste, CollutO3®, Ozoral® Gel (Innovares, Sant'Ilario d'Enza (RE) - Italy).

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-01-10
• Completion: 2026-01-20
• First posted: 2025-11-25
• Last updated: 2026-01-27

Locations

1 site across 1 country: Italy