Trials / Not Yet Recruiting
Not Yet RecruitingNCT07246876
Diagnostic Value of EBUS-Guided Transbronchial Mediastinal Cryobiopsy Versus Conventional Bronchoscopic Approaches for Stage I/II Sarcoidosis
- Status
- Not Yet Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 469 (estimated)
- Sponsor
- China-Japan Friendship Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) have high diagnostic yields for patients with sarcoidosis. However, a direct comparison between them has not been conducted. This randomized controlled trial aims to compare directly the diagnostic yield between EBUS-TBMC and EBUS-TBNA+EBB+TBLB in sarcoidosis.
Detailed description
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) have high diagnostic yields for patients with sarcoidosis. However, a direct comparison between them has not been conducted. Two questions remain need to be answered: (1) Does EBUS-TBMC have the same or better diagnostic sensitivity for sarcoidosis than EBUS-TBNA combined with standard bronchoscopic modalities (EBB or/and TBLB)? (2) Can combining EBUS-TBMC with standard bronchoscopic modalities further increase the diagnostic sensitivity for sarcoidosis? This study is designed as a randomised controlled trial to compare the diagnostic yield between EBUS-TBMC and conventional bronchoscopic approaches for diagnosing stage I/II sarcoidosis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | EBUS-TBNA-based sampling methods | Participants will receive an endobronchial biopsy and a transbronchial lung biopsy, followed by EBUS-TBNA. |
| PROCEDURE | EBUS-TBMC based sampling method | Participants will receive an endobronchial biopsy and a transbronchial lung biopsy, followed by EBUS-TBMC. |
Timeline
- Start date
- 2026-03-01
- Primary completion
- 2026-11-01
- Completion
- 2026-12-01
- First posted
- 2025-11-24
- Last updated
- 2026-02-06
Source: ClinicalTrials.gov record NCT07246876. Inclusion in this directory is not an endorsement.