NCT07244445

Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy

Dietary Pistachio Intake and Nutrition-Related Outcomes in Individuals Using GLP-1 Receptor Agonists: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (estimated)
• Sponsor: Ian J. Neeland, MD · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.

Conditions

• Dietary Change
• Obesity & Overweight
• Food Acceptance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Pistachios	Participants will eat 2 ounces, or about 53 grams, of dry-roasted, unsalted pistachios each day along with their regular diet
PROCEDURE	Dual-energy X-ray absorptiometry (DEXA) scans	DEXA scans will be used to measure body fat

Timeline

• Start date: 2026-01-29
• Primary completion: 2027-12-01
• Completion: 2027-12-01
• First posted: 2025-11-24
• Last updated: 2026-02-20

Locations

1 site across 1 country: United States