NCT07243821

Metabolic Syndrome and Prediabetes

Cohort Studies on Metabolic Syndrome and Prediabetes

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to establish a cohort of individuals with metabolic syndrome and prediabetes to enable long-term follow-up of risk factors, disease progression, and the development of obesity-related complications. The study will also monitor changes in nutritional status and physical function over time, in order to identify key prognostic determinants influencing clinical outcomes. Metabolic syndrome and prediabetes are chronic multisystem disorders, and poor long-term control is closely associated with the development of various complications. Moreover, malnutrition and functional decline are common comorbid conditions that further impair quality of life and impose a substantial burden on healthcare resources.

Detailed description

Metabolic syndrome has been recognized as a significant contributor to the development of major chronic diseases, including cerebrovascular disorders, cardiovascular disease, diabetes mellitus, and hypertension. Compared with the general population, individuals with metabolic syndrome exhibit an approximately sixfold increased risk of diabetes, fourfold risk of hypertension, threefold risk of dyslipidemia, and twofold risk of stroke and coronary heart disease. The condition is strongly influenced by dietary and lifestyle factors. Its core pathophysiological features are insulin resistance and central obesity, and there is a high degree of comorbidity between metabolic syndrome and prediabetes. The establishment of a comprehensive cohort and database for individuals with metabolic syndrome and prediabetes will facilitate the systematic collection of metabolic profiles and disease-related biomarkers. This will enable longitudinal analyses of systemic and organ-specific complications, their incidence, and predictive determinants, thereby strengthening disease risk stratification and early identification. This study aims to collect routine clinical, physiological, and nutritional data at regular intervals to examine associations among lifestyle behaviors, metabolic factors, physiological indicators, and the development of complications. Furthermore, it seeks to evaluate nutritional and functional status, identify potential prognostic biomarkers, and provide a foundation for individualized therapeutic approaches and integrated healthcare models.

Conditions

• Metabolic Syndrome
• Diabetes

Timeline

• Start date: 2025-10-31
• Primary completion: 2028-09-01
• Completion: 2028-09-01
• First posted: 2025-11-24
• Last updated: 2025-11-24

Locations

1 site across 1 country: Taiwan