NCT07243574

Night Owl Sleep Study: The Effect of Sleep on Fecal Microbiota

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 174 (estimated)
• Sponsor: Danisco · Industry
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to assess differences in the fecal microbiota and metabolome associated with insufficient and sufficient sleep, and to evaluate the response and recovery of the microbiota to changes in participant sleep profiles. Researchers will compare the effect of sleep intervention on both insufficient and sufficient sleepers to identify differences in fecal microbiota structure and function between cohorts during habitual sleep and during the sleep alteration intervention period.. Participants will be assigned to one of two cohorts based on their current sleep habits. Cohort 1 are participants who have insufficient sleep at baseline; this cohort will be assigned to spend 1.5 hours more in bed per night. Cohort 2 are participants who have sufficient sleep at baseline; this cohort will be assigned to spend 1.5 hours less in bed per night. The sleep intervention lasts for 14 days.

Conditions

• Sleep

Interventions

Type	Name	Description
BEHAVIORAL	Increase sleep by 90 minutes	For 14 days, participants will increase their nightly sleep by 90 minutes.
BEHAVIORAL	Decrease sleep by 90 minutes	For 14 days, participants will decrease their nightly sleep by 90 minutes.

Timeline

• Start date: 2025-09-17
• Primary completion: 2026-05-01
• Completion: 2026-07-01
• First posted: 2025-11-24
• Last updated: 2025-11-24

Locations

3 sites across 1 country: United States