NCT07242703

Efficacy of Ultraviolet B Phototherapy in the Management of Resistant and Relapsing Tinea Corporis and Tinea Cruris

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to assess the efficacy of narrow-band ultraviolet B (NB-UVB) phototherapy as a standalone treatment in patients with resistant and recurrent tinea. To evaluate the clinical and mycological improvement in response to NB-UVB therapy compared to standard anti-fungal treatment alone.

Detailed description

Randomized, parallel-group, two-arm clinical trial. Arm A (NB-UVB group): Patients receive narrowband UVB phototherapy only. Arm B (Itraconazole + Terbinafine group): Patients receive combined oral itraconazole and terbinafine. Allocation will be 1:1 using concealed randomization. Intervention: Intervention (Arm A): Patients in Arm A will receive narrowband UVB phototherapy (311 nm) three times per week for a total of 8 weeks. Starting dose: 280-320 mJ/cm² (based on Fitzpatrick skin type) Dose escalation: Increase by 10-20% each week as tolerated, with weekly monitoring for erythema or other adverse effects. Follow-up: All Arm A patients will be re-evaluated clinically and mycologically 8 weeks after completing the 8-week NB-UVB course (i.e., at week 16 from baseline) to assess sustained response and relapse. Intervention (Arm B): Patients in Arm B will receive oral itraconazole plus terbinafine concurrently: Itraconazole: 200 mg once daily for 8 weeks Terbinafine: 250 mg once daily for 8 weeks Follow-up: All Arm B patients will be re-evaluated clinically and mycologically 8 weeks after completing the 8-week antifungal course (also at week 16 from baseline) to assess sustained response and relapse. Monitoring: Weekly observation for erythema or side effects. A follow-up period of 8 weeks after the end of treatment will be included to assess relapse and sustained clinical/mycological improvement.

Conditions

• Fungal Resistance

Interventions

Type	Name	Description
DEVICE	NBUVB	Phototherapy device
DRUG	Itraconazole + terbinafine	Antifungal drugs

Timeline

• Start date: 2025-12-01
• Primary completion: 2026-04-01
• Completion: 2026-05-01
• First posted: 2025-11-21
• Last updated: 2025-11-21