NCT07242066

Effects of Dietary Nitrate and Vitamin C Co-supplementation on Blood Pressure and Endothelial Function in Overweight Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Nottingham · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The investigators have shown in two short-term studies in healthy, young participants that the combined supplementation of inorganic nitrate with vitamin C has beneficial effects on blood pressure and blood vessel wall stiffness. However, the effects of the combined supplementation have not been tested in individuals at greater cardiovascular disease risk. The investigators would like to show whether inorganic nitrate and vitamin C will produce greater effects on blood pressure and endothelial function when compared to inorganic nitrate alone versus the placebo treatment in people at greater risk of cardiovascular disease.

Conditions

• Blood Pressure

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Beetroot juice plus vitamin C tablet	Concentrated beetroot juice (70 ml in the morning before breakfast and 70 ml in the evening before dinner) plus Vitamin C tablets (500mg/tablet)
DIETARY_SUPPLEMENT	Beetroot juice plus placebo tablet	Concentrated beetroot juice (70ml in the morning and 70 ml in the evening) plus placebo tablets (containing 500 mg of the non-nutritive sweetener aspartame)
DIETARY_SUPPLEMENT	Nitrate-depleted beetroot juice plus placebo tablet	nitrate-depleted beetroot juice (70ml in the morning and 70 ml in the evening) plus placebo tablets (containing 500 mg of the non-nutritive sweetener aspartame)

Timeline

• Start date: 2024-11-25
• Primary completion: 2025-08-01
• Completion: 2025-08-22
• First posted: 2025-11-21
• Last updated: 2025-12-02

Locations

1 site across 1 country: United Kingdom